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roadmap epigenomics data portal  (Epigenomics ag)

 
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    Epigenomics ag roadmap epigenomics data portal
    Roadmap Epigenomics Data Portal, supplied by Epigenomics ag, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/roadmap+epigenomics+data/roadmap+epigenomics+data+portal/pm40346707-365-12-13
    Average 90 stars, based on 1 article reviews
    roadmap epigenomics data portal - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    other:

    Article Title: Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes
    Article Snippet: Roadmap Epigenomics data can be visualized and downloaded here: https://egg2.wustl.edu/roadmap/web_portal/ .

    Article Title: Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.
    Article Snippet: Roadmap Epigenomics data can be visualized and downloaded here: https://egg2.wustl.edu/roadmap/web_portal/.

    Article Title: Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan.
    Article Snippet: Each color corresponds to a unique tissue type, as indicated by Roadmap Epigenomics data.

    Functional Assay:

    Article Title: Antisense-mediated regulation of exon usage in the elastic spring region of Titin modulates sarcomere function
    Article Snippet: .. The transcriptional start site of TTN-AS1 -276 lies ∼2500 bp downstream of TTN and a high-quality map of functional genomic regions based on Roadmap Epigenomics data showed that this genomic region is an active promoter in human atrial and ventricular tissue (see , ). ..

    GWAS:

    Article Title: Supplement: The 26th Annual Conference of the International Society for Bipolar Disorders, Reykjavik, Iceland, 29 September - 1 October 2024.
    Article Snippet: Introduction: Increasing evidence suggests an accelerated aging in heart of bipolar disorder (BD).. Lithium, a mainstay medication used to BD, exhibits antiaging properties and cardioprotective potentials.. This preclinical study investigated whether lithium regulated Klotho (an antiaging protein) in human cardiac fibroblasts and protected cardiac function related to cardiac fibrosis in rats with maniclike behaviors.

    Gene Expression:

    Article Title: Supplement: The 26th Annual Conference of the International Society for Bipolar Disorders, Reykjavik, Iceland, 29 September - 1 October 2024.
    Article Snippet: Introduction: Increasing evidence suggests an accelerated aging in heart of bipolar disorder (BD).. Lithium, a mainstay medication used to BD, exhibits antiaging properties and cardioprotective potentials.. This preclinical study investigated whether lithium regulated Klotho (an antiaging protein) in human cardiac fibroblasts and protected cardiac function related to cardiac fibrosis in rats with maniclike behaviors.

    Binding Assay:

    Article Title: Supplement: The 26th Annual Conference of the International Society for Bipolar Disorders, Reykjavik, Iceland, 29 September - 1 October 2024.
    Article Snippet: Introduction: Increasing evidence suggests an accelerated aging in heart of bipolar disorder (BD).. Lithium, a mainstay medication used to BD, exhibits antiaging properties and cardioprotective potentials.. This preclinical study investigated whether lithium regulated Klotho (an antiaging protein) in human cardiac fibroblasts and protected cardiac function related to cardiac fibrosis in rats with maniclike behaviors.

    Expressing:

    Article Title: Supplement: The 26th Annual Conference of the International Society for Bipolar Disorders, Reykjavik, Iceland, 29 September - 1 October 2024.
    Article Snippet: Introduction: Increasing evidence suggests an accelerated aging in heart of bipolar disorder (BD).. Lithium, a mainstay medication used to BD, exhibits antiaging properties and cardioprotective potentials.. This preclinical study investigated whether lithium regulated Klotho (an antiaging protein) in human cardiac fibroblasts and protected cardiac function related to cardiac fibrosis in rats with maniclike behaviors.

    Activation Assay:

    Article Title: Supplement: The 26th Annual Conference of the International Society for Bipolar Disorders, Reykjavik, Iceland, 29 September - 1 October 2024.
    Article Snippet: Introduction: Increasing evidence suggests an accelerated aging in heart of bipolar disorder (BD).. Lithium, a mainstay medication used to BD, exhibits antiaging properties and cardioprotective potentials.. This preclinical study investigated whether lithium regulated Klotho (an antiaging protein) in human cardiac fibroblasts and protected cardiac function related to cardiac fibrosis in rats with maniclike behaviors.



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    eForge analysis (Consolidated <t>Roadmap</t> Epigenomics) of hypermethylated CpGs showed significant enrichment in different fetal tissues ( a ) and hypomethylated CpGs showing non-significant enrichment in different fetal tissues ( b ). The x -axis represents the type of tissues, while y -axis represents the p value (−log10) showing significance.
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    DNA methylation changes across the genome in patients with TET2 mt CH and DNMT3A mt CH. (A) Overview of patient cohorts from whom PBMCs were collected and analyzed in this study using DNA methylation (Illumina Methylation EPIC array), single-cell proteogenomics (Tapestri assay), scRNA-seq (10x Genomics), multiome (10x Genomics), and GoTChA modalities. Mutations and VAFs are shown above the figurines. Patient ages and modalities used are shown below the figurines. Sample identifier is shown inside the figurines. (B) Box plot showing the comparison of global DNA methylation between DNMT3A mt and TET2 mt CH. There was no significant difference by Wilcoxon signed-rank test ( P = .057). (C) Density plot demonstrating DNA methylation differences between TET2 mt CH and DNMT3A mt CH, primarily affecting highly methylated CpGs (β > 0.75; Kolmogorov-Smirnov test, P < 2.2 × 10 −16 ). (D) Circos plot showing the number, genomic location, and density of differentially methylated regions between TET2 mt CH and DNMT3A mt CH. There was an increased number of hypomethylated sites in DNMT3A mt CH compared with TET2 mt CH. (E) Functional annotation of the differentially methylated regions (with Δβ > 10% and P < .010) using the <t>ENCODE</t> Epigenomics <t>Roadmap</t> PBMC reference data. Hypermethylation of Enh and promoters (TssA, TssAFlnk) was more commonly observed in DNMT3A mt CH (compared with TET2 mt CH), whereas the hypomethylation observed in DNMT3A CH was predominately found at actively transcribed states (Tx, TxWk). scATAC, single-cell ATAC; TssA, active transcription start site; TssAFlnk, Flanking bivalent transcription start sites.
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    Image Search Results


    eForge analysis (Consolidated Roadmap Epigenomics) of hypermethylated CpGs showed significant enrichment in different fetal tissues ( a ) and hypomethylated CpGs showing non-significant enrichment in different fetal tissues ( b ). The x -axis represents the type of tissues, while y -axis represents the p value (−log10) showing significance.

    Journal: Lifestyle Genomics

    Article Title: Exploring Differentially Methylated Genes among Preterm Birth and Full-Term Birth

    doi: 10.1159/000543372

    Figure Lengend Snippet: eForge analysis (Consolidated Roadmap Epigenomics) of hypermethylated CpGs showed significant enrichment in different fetal tissues ( a ) and hypomethylated CpGs showing non-significant enrichment in different fetal tissues ( b ). The x -axis represents the type of tissues, while y -axis represents the p value (−log10) showing significance.

    Article Snippet: Similarly, analysis using Roadmap Epigenomics DHS (RED) data revealed significant enrichment ( FDR p < 0.05 ) of hypermethylated CpGs in fetal tissues such as fetal adrenal, brain, heart, and small and large intestine, while hypomethylated CpGs showed no significant enrichment (online suppl.

    Techniques:

    DNA methylation changes across the genome in patients with TET2 mt CH and DNMT3A mt CH. (A) Overview of patient cohorts from whom PBMCs were collected and analyzed in this study using DNA methylation (Illumina Methylation EPIC array), single-cell proteogenomics (Tapestri assay), scRNA-seq (10x Genomics), multiome (10x Genomics), and GoTChA modalities. Mutations and VAFs are shown above the figurines. Patient ages and modalities used are shown below the figurines. Sample identifier is shown inside the figurines. (B) Box plot showing the comparison of global DNA methylation between DNMT3A mt and TET2 mt CH. There was no significant difference by Wilcoxon signed-rank test ( P = .057). (C) Density plot demonstrating DNA methylation differences between TET2 mt CH and DNMT3A mt CH, primarily affecting highly methylated CpGs (β > 0.75; Kolmogorov-Smirnov test, P < 2.2 × 10 −16 ). (D) Circos plot showing the number, genomic location, and density of differentially methylated regions between TET2 mt CH and DNMT3A mt CH. There was an increased number of hypomethylated sites in DNMT3A mt CH compared with TET2 mt CH. (E) Functional annotation of the differentially methylated regions (with Δβ > 10% and P < .010) using the ENCODE Epigenomics Roadmap PBMC reference data. Hypermethylation of Enh and promoters (TssA, TssAFlnk) was more commonly observed in DNMT3A mt CH (compared with TET2 mt CH), whereas the hypomethylation observed in DNMT3A CH was predominately found at actively transcribed states (Tx, TxWk). scATAC, single-cell ATAC; TssA, active transcription start site; TssAFlnk, Flanking bivalent transcription start sites.

    Journal: Blood Advances

    Article Title: Single-cell multiomics reveal divergent effects of DNMT3A- and TET2- mutant clonal hematopoiesis in inflammatory response ∗

    doi: 10.1182/bloodadvances.2024014467

    Figure Lengend Snippet: DNA methylation changes across the genome in patients with TET2 mt CH and DNMT3A mt CH. (A) Overview of patient cohorts from whom PBMCs were collected and analyzed in this study using DNA methylation (Illumina Methylation EPIC array), single-cell proteogenomics (Tapestri assay), scRNA-seq (10x Genomics), multiome (10x Genomics), and GoTChA modalities. Mutations and VAFs are shown above the figurines. Patient ages and modalities used are shown below the figurines. Sample identifier is shown inside the figurines. (B) Box plot showing the comparison of global DNA methylation between DNMT3A mt and TET2 mt CH. There was no significant difference by Wilcoxon signed-rank test ( P = .057). (C) Density plot demonstrating DNA methylation differences between TET2 mt CH and DNMT3A mt CH, primarily affecting highly methylated CpGs (β > 0.75; Kolmogorov-Smirnov test, P < 2.2 × 10 −16 ). (D) Circos plot showing the number, genomic location, and density of differentially methylated regions between TET2 mt CH and DNMT3A mt CH. There was an increased number of hypomethylated sites in DNMT3A mt CH compared with TET2 mt CH. (E) Functional annotation of the differentially methylated regions (with Δβ > 10% and P < .010) using the ENCODE Epigenomics Roadmap PBMC reference data. Hypermethylation of Enh and promoters (TssA, TssAFlnk) was more commonly observed in DNMT3A mt CH (compared with TET2 mt CH), whereas the hypomethylation observed in DNMT3A CH was predominately found at actively transcribed states (Tx, TxWk). scATAC, single-cell ATAC; TssA, active transcription start site; TssAFlnk, Flanking bivalent transcription start sites.

    Article Snippet: We then annotated the differentially methylated regions using the ENCODE Epigenomics Roadmap reference data.

    Techniques: DNA Methylation Assay, Methylation, Comparison, Functional Assay